RESUMO
To explore the value of diffusion kurtosis imaging in the changes of spinal cord microstructures in patients with early cervical spondylotic myelopathy.Twenty nine patients with cervical myelopathy were selected in this study. All images were acquired on a 3.0 T MR scanner (Skyra, Siemens Medical Systems, Germany). The imaging parameters for diffusion kurtosis imaging were as follows: repetition time/echo time, 3000/91 ms; averages, 2; slice thickness/gap, 3/0.3âmm; number of slices, 17; field of view, 230â×â230âmm; Voxel size, 0.4 × 0.4 × 3.0âmm; 3 b-values (0, 1000, and 2000âs/mm) with diffusion encoding in 20 directions for each b-value. Values for fractional anisotropy, mean diffusivity, and mean diffusional kurtosis (MK) were calculated and compared between unaffected and affected spinal cords.In all patients MK was significantly lower in normal appearing spinal cords adjacent to the affected cervical spinal cords than in normal cervical spinal cords (0.862â±â0.051 vs 0.976â±â0.0924, Pâ<â.0001), but the difference of fractional anisotropy and apparent diffusion coefficient was no significant (Pâ>â.05). The affected cervical spinal cords had lower MK (0.716â±â0.0753), FA and higher apparent diffusion coefficient than normal cervical spinal cords (Pâ<â.001).MK values in the cervical spinal cord may reflect microstructural changes of spinal cord damage in cervical myelopathy, and it could potentially provide more information that obtained with conventional diffusion metrics.
Assuntos
Imagem de Tensor de Difusão , Doenças da Medula Espinal/dietoterapia , Medula Espinal/diagnóstico por imagem , Medula Espinal/patologia , Espondilose/diagnóstico por imagem , Idoso , Idoso de 80 Anos ou mais , Vértebras Cervicais , Estudos de Viabilidade , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Doenças da Medula Espinal/complicações , Espondilose/complicaçõesRESUMO
No disponible
Assuntos
Humanos , Feminino , Idoso de 80 Anos ou mais , Deficiência de Vitamina B 12 , Micronutrientes , Doenças da Medula Espinal/dietoterapia , Cobre/deficiência , Mielite/complicações , Diagnóstico DiferencialAssuntos
Cobre/administração & dosagem , Cobre/deficiência , Dieta , Adulto , Cobre/sangue , Feminino , Humanos , Transtornos dos Movimentos/sangue , Transtornos dos Movimentos/dietoterapia , Transtornos das Sensações/sangue , Transtornos das Sensações/dietoterapia , Doenças da Medula Espinal/sangue , Doenças da Medula Espinal/dietoterapiaRESUMO
MOTIVATION: Text mining systems aim at knowledge discovery from text collections. This work presents our text mining algorithm and demonstrates its use to uncover information that could form the basis of new hypotheses. In particular, we use it to discover novel uses for Curcuma longa, a dietary substance, which is highly regarded for its therapeutic properties in Asia. RESULTS: Several disease were identified that offer novel research contexts for curcumin. We analyze select suggestions, such as retinal diseases, Crohn's disease and disorders related to the spinal cord. Our analysis suggests that there is strong evidence in favor of a beneficial role for curcumin in these diseases. The evidence is based on curcumin's influence on several genes, such as COX-2, TNF-alpha, JNK, p38 MAPK and TGF-beta. This research suggests that our discovery algorithm may be used to suggest novel uses for dietary and pharmacological substances. More generally, our text mining algorithm may be used to uncover information that potentially sheds new light on a given topic of interest. AVAILABILITY: Contact authors.
Assuntos
Doença de Crohn/dietoterapia , Curcumina/uso terapêutico , Dietoterapia , MEDLINE , Processamento de Linguagem Natural , Doenças Retinianas/dietoterapia , Doenças da Medula Espinal/dietoterapia , Indexação e Redação de Resumos/métodos , Inteligência Artificial , Humanos , Estatística como AssuntoRESUMO
Neurologic complications associated with vitamin B12 deficiency include spinal cord degeneration, peripheral neuropathy and alteration of mental status. The possibility of vitamin B12 deficiency must be considered in all patients with these nervous system disorders, even in those who do not have anemia. If treatment is started early, most of the neurologic deficits will resolve. Delayed therapy usually halts the progression of the disease, but permanent sequelae may occur.